tobacco

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  TON vs. Smoking Bans and Smoker/Nonsmoker Disparity

  The Titles of Nobility Clauses (Art. I §9 Cl. 8 federal + Art. I §10 Cl. 1) forbid government from granting or enforcing enduring legal hierarchies of superior/inferior status by sovereign fiat; no state-created nobility or serfdom, no enduring privileged or disadvantaged legal classes. Smoking bans and the resulting smoker/nonsmoker disparity are TON-vulnerable in several…

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  The Smoker’s Paradox Through the SCN⁻ Lens

  The “smoker’s paradox” has puzzled researchers for decades. In certain situations, smokers show outcomes that look unexpectedly better than non‑smokers in a way that doesn’t line up with the standard narrative. For years, the default explanation was nicotine. But that theory collapses the moment you look at the data. If nicotine were the protective factor,…

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  Tobacco Smoke, SCN⁻, and Glucuronic Acid as Dual Terrain Provocateurs

  A Ritual Fire That Activates Both Salt and Sugar Filtration Tobacco smoke, long cast as villain, is reframed here as ritual fire—a biochemical and symbolic stimulant that provokes two terrain guardians: Together, they form a dual filtration system—salt and sugar, volatility and sweetness, defense and purification. Tobacco smoke activates both, not by accident, but by…

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  Biochemical Connection Between Altitude-Induced Sodium Depletion and The Use of Tobacco Smoke in High-Altitude Mountaineering

  There’s a glyphic and biochemical connection between altitude-induced sodium depletion and the historical use of tobacco smoke in high-altitude mountaineering. It’s not officially recommended, but it reflects a deeper terrain logic: compressed oxygen, vascular instability, and redox buffering collapse. Altitude and Sodium Depletion At high altitudes: Altitude compresses terrain—sodium is the first to vanish. Tobacco…

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  Secondhand Thiocyanate (SCN⁻)

  Secondhand tobacco smoke does contain hydrogen cyanide (HCN), which the body metabolizes into thiocyanate (SCN⁻). Studies show that nonsmokers exposed to tobacco smoke, especially in enclosed environments, can exhibit elevated SCN⁻ levels in saliva, though not as high as active smokers. How the Transfer Works

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  Is Thiocyanate exclusive to tobacco smoke?

  Thiocyanate (SCN⁻) is NOT exclusive to tobacco smoke. It’s a metabolite of cyanide, and cyanide itself is released when nitrogen- and sulfur-containing organic compounds are burned. That includes: Once cyanide is absorbed, the body detoxifies it via rhodanese enzymes, converting it into thiocyanate, which is then excreted in saliva, sweat, and urine. So yes—any combustion…

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  Is Thiocyanate more important than nicotine when it comes to tobacco?

  Thiocyanate Over Nicotine: Reframing the Smoker’s Paradox Through Ionic Terrain and Immunologic Logic Abstract The so-called smoker’s paradox – where smokers exhibit reduced severity in conditions like ulcerative colitis, Parkinson’s, and even acute respiratory distress – has long baffled researchers. While nicotine is often invoked as the protective agent, emerging evidence suggests this is a…

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  Tobacco-derived 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice (decreases levels of pro-inflammatory cytokines; improves memory function; activates STAT3, Akt1, and CREB phosphorylation; and upregulates the mRNA levels of ORM2, GDNF, and C3) independent of the α7 nicotinic receptor

  Rojas-Colón, L.A., Dash, P.K., Morales-Vías, F.A. et al. 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice. J Neuroinflammation 18, 95 (2021). https://doi.org/10.1186/s12974-021-02136-9 LPS: Lipopolysaccharide “4R protects the hippocampus against inflammation and memory impairments triggered by LPS by lowering TNF-α and IL-1β levels and activation of the Akt1 and CREB signaling pathways. Astrocyte proteins involved in neuronal survival also…

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  Tobacco-derived 4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation

  Fu, Hefei et al. “4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation.” Brain research bulletin vol. 179 (2022): 74-82. doi:10.1016/j.brainresbull.2021.12.007 In the search for novel compounds to treat neurodegenerative diseases, we found that 4R-cembranoid, an extract from tobacco leaves, may be a lead compound with anti-inflammatory and neuroprotective properties. 4R belongs to the…

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  Patent for protecting and treating organophosphate-induced neuronal injury with tobacco-derived cembranoids and analogues

  Ford, Byron, Ferchmin Peter, Eterovic, Vesna, Methods and compositions for protecting and treating neuroinjury (Patent), United States Grant US-8530525-B2 Assignee: Central University of the Caribbean, Morehouse School of Medicine, Status: Active, Expires 2031-05-19, Document history 2013-09-10 Publication date, 2010-07-01 Filing date, 2009-07-14 Priority date. Funded by National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and…