In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen[1] and von Willebrand factor and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa,… Read more.

* = group; ** = not listed on hcdm CD1* MHC-like molecule that presents lipid molecules CD1a CD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A gene. An antigen-presenting… Read more.

Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes. Tetraspanins, also referred to as the transmembrane 4 superfamily (TM4SF) proteins, have four transmembrane alpha-helices and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL… Read more.

Arrestin Oguchi disease 1 Myelin Pelizaeus–Merzbacher disease – Dejerine–Sottas disease – Charcot–Marie–Tooth disease 1B, 2J Pulmonary surfactant Surfactant metabolism dysfunction 1, 2 Cell adhesion molecule IgSF CAM:OFC7 – Cadherin: DSG… Read more.

X-linked dominant inheritance X-linked dominant X-linked hypophosphatemia – Focal dermal hypoplasia – Fragile X syndrome – Aicardi syndrome – Incontinentia pigmenti – Rett syndrome – CHILD syndrome – Lujan–Fryns syndrome… Read more.

Inborn errors of purine–pyrimidine metabolism are a class of inborn error of metabolism disorders specifically affecting purine metabolism and pyrimidine metabolism. An example is Lesch–Nyhan syndrome. Urine tests may be of use in identifying some of these… Read more.

Orotidine 5′-phosphate decarboxylase (OMP decarboxylase) or orotidylate decarboxylase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the decarboxylation of orotidine monophosphate (OMP) to form uridine monophosphate (UMP). The function of this enzyme is essential to the de novo biosynthesis of the pyrimidine nucleotides uridine… Read more.