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Baruch Samuel Blumberg (1925 – 2011) Wiki
He was also president of the American Philosophical Society from 2005 until his death. Blumberg and Gajdusek received the Nobel Prize for discovering “new mechanisms for the origin and dissemination of infectious diseases.” Blumberg identified the hepatitis B virus, and later developed its diagnostic test and vaccine. Biography Early life and education Blumberg was born in Brooklyn, New York, into a Jewish family, the son of
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Daniel Carleton Gajdusek (1923 – 2008) Wiki
His papers are held at the National Library of Medicine in Bethesda, Maryland and at the American Philosophical Society in Philadelphia, Pennsylvania. Early life and education Gajdusek’s father, Karol Gajdusek, was a Slovak butcher from Smrdáky, Kingdom of Hungary, now Slovakia. His mother Ottilia Dobróczki, and maternal grandparents, ethnic Hungarians of the Calvinist faith, emigrated from Debrecen, Hungary. Gajdusek was born in Yonkers, New York, and graduated
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A History of Hepatitis B Vaccine
Preliminary work In 1963, the American physician/geneticist Baruch Blumberg, working at the Fox Chase Cancer Center, discovered what he called the “Australia Antigen” (HBsAg) in the serum of an Australian Aboriginal person. In 1968, this protein was found to be part of the virus that causes “serum hepatitis” (hepatitis B) by virologist Alfred Prince. In 1976, Blumberg won the Nobel Prize in
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Wolf Szmuness, epidemiologist and former roommate of a future Pope John Paul II, is named in an AIDS origin theory involving his hepatitis B vaccine trials
Wolf Szmuness (1919 – 1982) was a Polish-born epidemiologist who emigrated to and worked in the United States. He conducted research at the New York Blood Center and, from 1973, he was director of the Center’s epidemiology laboratory. He designed and conducted the trials for the first vaccine to prove effective against hepatitis B. European beginnings Szmuness was born in Warsaw, Poland on 12 March 1919.
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Adamalysin II, the Protein World’s Very Own Eastern Diamondback Rattlesnake Superstar
Adamalysin II, alias proteinase II, a 24 kDa zinc-endopeptidase isolated from the snake venom of the Eastern diamondback rattlesnake Crotalus adamanteus, is a prototype, of the proteolytic domain of snake venom metalloproteinases and of domains found in mammalian reproductive tract proteins.
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Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang YM, Rosemblit N, Marks AR. Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J Cell Biol. 2001 May 14;153(4):699-708. doi: 10.1083/jcb.153.4.699. PMID: 11352932; PMCID: PMC2192391.
Abstract Ryanodine receptors (RyRs), intracellular calcium release channels required for cardiac and skeletal muscle contraction, are macromolecular complexes that include kinases and phosphatases. Phosphorylation/dephosphorylation plays a key role in regulating the function of many ion channels, including RyRs. However, the mechanism by which kinases and phosphatases are targeted to ion channels is not well understood.
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Oxytocin: The Molecular Maestro of Love and Labor
Buckle up, hormone enthusiasts. We’re about to take a wild ride into the world of oxytocin, the “love hormone” that’s been playing Cupid in our bodies since the dawn of mammalian evolution. This tiny peptide packs a punch that would make even Hercules jealous. Picture this: a molecule barely 1007 Da in size, strutting around
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Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid. Valine is essential in humans, meaning the body cannot synthesize it; it
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Insall R. Dispatch. Dictyostelium chemotaxis: fascism through the back door? Curr Biol. 2003 Apr 29;13(9):R353-4. doi: 10.1016/s0960-9822(03)00274-4. PMID: 12725750.
Abstract Aggregating Dictyostelium cells secrete cyclic AMP to attract their neighbours by chemotaxis. It has now been shown that adenylyl cyclase is enriched in the rear of cells, and this localisation is required for normal aggregation. Dictyostelium discoideum cells undergo a major lifestyle change when they get hungry. They grow as unicellular amoebas, but when food starts to
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