physiology
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Relaxin
We’re about to dive into the wild world of Relaxin, the protein hormone that’s been turning heads since 1926 when Frederick Hisaw first stumbled upon it. This isn’t your average hormone – it’s a multitasking marvel that’s about to blow your mind! Researchers say this tiny protein, barely 6000 Da in size, is strutting around…
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Theca folliculi
The theca folliculi comprise a layer of the ovarian follicles. They appear as the follicles become secondary follicles. The theca are divided into two layers, the theca interna and the theca externa.[1] Theca cells are a group of endocrine cells in the ovary made up of connective tissue surrounding the follicle. They have many diverse functions, including promoting folliculogenesis and recruitment of a single…
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HFE H63D & VO2 max
SMOKE EM IF YOU GOT EM The HFE H63D is a single-nucleotide polymorphism in the HFE gene (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption. Homozygous H63D variant can occasionally be the cause of hemochromatosis. It is also…
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Freemartin
A freemartin or free-martin (sometimes martin heifer) is an infertile female cattle with masculinized behavior and non-functioning ovaries.[1] Phenotypically, the animal appears female, but various aspects of female reproductive development are altered due to acquisition of anti-Müllerian hormone from the male twin.[2] Genetically, the animal is chimeric: karyotypy of a sample of cells shows XX/XY chromosomes. The animal originates as a female (XX), but acquires the male (XY) component in utero by exchange of…
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Connection (and difference) between buccal membrane and buccopharyngeal membrane
A Tale of Two Tissues Prepare yourself for a thrilling journey into the world of microscopic membranes! Today, we’re diving deep into the oral cavity to explore the buccal membrane and its embryonic cousin, the buccopharyngeal (aka oropharyngeal) membrane. It’s a story of similarities, differences, and developmental drama! Act I: The Buccal BombshellOur first star,…
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Embryonic Intrigue That’ll Make Your Buccopharyngeal Membrane Quiver with Excitement
Picture, if you will, the humble beginnings of life, where a thin membrane known as the buccopharyngeal membrane (or oropharyngeal membrane for those who like their words extra fancy) plays the role of the ultimate gatekeeper between the primitive mouth and pharynx. It’s like nature’s very own “You shall not pass!” moment, but with fewer…
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Rete Pegs Wiki
Rete pegs (aka rete processes or rete ridges or papillae) are epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes.
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Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang YM, Rosemblit N, Marks AR. Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J Cell Biol. 2001 May 14;153(4):699-708. doi: 10.1083/jcb.153.4.699. PMID: 11352932; PMCID: PMC2192391.
Abstract Ryanodine receptors (RyRs), intracellular calcium release channels required for cardiac and skeletal muscle contraction, are macromolecular complexes that include kinases and phosphatases. Phosphorylation/dephosphorylation plays a key role in regulating the function of many ion channels, including RyRs. However, the mechanism by which kinases and phosphatases are targeted to ion channels is not well understood.…
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Oxytocin: The Molecular Maestro of Love and Labor
Buckle up, hormone enthusiasts. We’re about to take a wild ride into the world of oxytocin, the “love hormone” that’s been playing Cupid in our bodies since the dawn of mammalian evolution. This tiny peptide packs a punch that would make even Hercules jealous. Picture this: a molecule barely 1007 Da in size, strutting around…
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